Job Description

Director/Senior Director, Regional Medical Affairs - Midwest

Work from Home

About Stoke:

Stoke Therapeutics (Nasdaq: STOK) is a biotechnology company dedicated to restoring protein expression by harnessing the bodys potential with RNA medicine. Stoke is developing antisense oligonucleotides (ASOs) to selectively restore naturally occurring protein levels. Stokes first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke entered into a strategic collaboration with Biogen in 2025 to develop and commercialize zorevunersen for Dravet syndrome. Under the collaboration, Stoke retains exclusive rights for zorevunersen in the United States, Canada, and Mexico; Biogen receives exclusive rest of world commercialization rights

Stokes initial focus for its TANGO platform is on diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency).

Stoke has identified STK-002 as a clinical candidate for the potential treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. The company is also pursuing a potential new medicine for Syngap1, a severe and rare neurodevelopmental disorder, in collaboration with Acadia Pharmaceuticals.

Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for the Companys proprietary approach.

Position Purpose:

The Director/Senior Director, Medical Affairs will be a core member ofthe global medical affairs team and will help establish core medical capabilities at Stoke Therapeutics. This is a field-based role and will primarily be responsible for representing Stoke Therapeutics with a network of external clinical experts or key opinion leaders (KOLs) in a regional area, while advancing prioritized Medical Affairs activities in collaboration with cross-functional teams. The role will initially be an individual contributor role, actively engaging a defined group of Stoke clinical investigators and key opinion leaders (KOLs) in developmental and epileptic encephalopathies (DEEs) in the US primarily, while also supporting international investigator and KOL engagement as needed.

Key Responsibilities:

• Work closely with clinical operations and development teams to support Stoke clinical study efforts, including site identification and engagement to advance enrollment while fostering collaborative research relationships with academic and community KOLs.
• Establish and maintain highly credible, scientific relationships with academic and medical thought leaders.
• Work closely with internal team members to facilitate and support congress strategy at scientific meetings, including KOL engagement planning, insight gathering on key topics, and interpretative reports to share with cross functional teams.
• Develop, share, and discuss ongoing clinical insights with cross-functional members to ensure awareness and understanding of KOL perspectives to inform and guide strategic decision-making.
• Develop strategic profiles for top experts and clinical staff at centers of comprehensive care, to help identify key opportunities for ongoing education and collaboration.
• Develop key performance and reputation measures to ensure ongoing alignment of Stoke activities to KOL and HCP expectations and needs.
• Collaborate closely with other functions including clinical, commercial and PR/IR/Advocacy to engage and support external stakeholder needs through activities such as scientific education, advisory boards, investigator meetings, publications, congresses, and other activities of interest.
• Must be able to perform duties typically associated with a normal office environment when not traveling.
• All other duties as assigned.

Required Skills & Experience:

• Advanced scientific or clinical degree, with at least 10+ years in relevant clinical/scientific fields and 5+ years of Medical Affairs experience, with significant focus on field medical activities.
• Experience with prelaunch and rare diseases in epilepsy, neurology highly preferred.
• Prior track record of success and proficiency in role working directly with clinical and academic experts is required.
• Excellent verbal and written communication skills, and exceptional interpersonal skills.
• Demonstrated skills in leading and mentoring others.
• Good judgment, ability to adapt and change in a shifting environment.
• A strategic, passionate, self-starter who takes initiative.
• Ability to work independently and function effectively as a team member.
• Excellent problem-solving skills.
• Valid driver's license and the ability to travel as necessary.

Location(s):

Stoke operates in Bedford, MA. This position is remote, field- based in the continental United States, and is responsible for a regionally designated area.

Travel:

This position will require approximately 60%+ travel, including the ability to travel overnight, internationally, and occasionally on weekends.

Culture & Values:

At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individuals needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation.

Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging Committee (DIB) underscores the importance of DIB to who we are and what we do.

Benefits & Compensation:

At Stoke Therapeutics we are proud to offer comprehensive and competitive employee benefits, including medical, dental and vision insurance; life, long and short-term disability insurance; Paid Parental Leave; a 401K program with company match, unlimited vacation time, and an Employee Stock Purchase Program (ESPP). Compensation is market competitive for the industry and directly commensurate with experience. All positions are bonus and stock eligible.

Interested candidates: Please visit Stokes website to learn more and apply directly to the position listed on our Career Center .

All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status.

Stoke participates in E-Verify.

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Stoke is aware ofthepotential forrecruiting scams from individuals, organizations and internet sitesthatclaim to represent Stokes Human Resources team. Our company utilizes a formal interview process to identify candidates for open positions, and doesnotconduct interviews using third party websites, social media platforms, or through applications such as Telegram, WhatsApp or Flock. We also will never ask for money or fees at any point during the interview process. Current open positions can be viewed on our Job Opportunities page . Those who observe suspicious recruiting activity involving Stoke are encouraged to report it to info@stoketherapeutics.com as well as to the Internet Crime Complaint center at .

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Stoke does not accept unsolicited recruitment support from external parties. Candidates or resumes submitted to Stoke by external firms without a signed contractand/or without Stokes initiation for assistance with respective search will be deemed unsolicited in nature, and no fee will be paid in the event the candidate is hired.

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